Has a Formula Been Found to Reverse Aging?


Written by Emel Gerdaneri.

Has a Formula Been Found to Reverse Aging?

A new and very important study has been published. It can be a turning point in reversing aging. This research was published in the journal Cell.

Harvard University's Dr. With this research, David Sinclair and his colleagues found an answer to the question of what triggers aging.

Sinclair and colleagues were able to restore some biological signs of youth to the animals by aging the mice on an accelerated timescale while simultaneously reversing the effects of this aging.

According to the theory in the research; “The root cause of aging is not mutations in DNA, but errors in epigenetic instructions that somehow go awry. ” and this is reversible.

agingEpigenetics; similar to the instructions in which tailors use patterns to sew shirts, trousers or jackets.

The starting fabric is the same, but the pattern determines what shape and function the final garment will take.

DNA hardware is epigenetic software. However, sometimes it is necessary to restart the system because this system is corrupted.

Distorted signals that put cells on the aging path have been deleted

aging pathThe research team developed a way to reinitialize a backup copy of epigenetic instructions in mice, erasing the corrupted signals that put cells on the senescence path.

“This could mean that many diseases, including chronic conditions like heart disease and even neurodegenerative disorders like Alzheimer's, can be largely treated by reversing the aging process that leads to them.

The Introduction to the Article Published on sciencedirect.com...

Science Direct
All living things experience an increase in entropy, which manifests itself as a loss of genetic and epigenetic information.

In yeast, epigenetic information is lost over time due to repositioning of chromatin-modifying proteins according to DNA breaks, causing cells to lose their identity, a feature of yeast senescence.

Using a system called "ICE" (inducible changes in the epigenome), we found that faithful DNA repair action promotes aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular differentiation, senescence, and progression.

DNA methylation clock reversible by OSK-mediated rejuvenation. These data are consistent with the information theory of aging, which states that loss of epigenetic information is a reversible cause of aging.


Written on 24/01/2023

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Last Update: 24/01/2023

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